Paul Pogba may start for Manchester United after making his return from injury as a substitute against Watford.
Diogo Dalot is another available option but Eric Bailly, Angel Gomes and Timothy Fosu-Mensah are still missing.
Newcastle United are expected to be without Paul Dummett because of a groin injury but Jetro Willems has returned to training and may feature.
Allan Saint-Maximin, Jamaal Lascelles, Ciaran Clark, Matt Ritchie and Ki Sung-Yeung all remain out for the Magpies.
Steve Bruce has intimated Andy Carroll will not play the full festive programme so he could be rested.
Manchester United manager Ole Gunnar Solskjaer: “It’s going to be difficult to break Newcastle down. I expect that we’ll get the fair share of the possession. We were disappointed when we had more than 70% possession up there [in the reverse fixture] and we lost the game.
“One of the good things about our team this year, we have reacted well after bad results. We haven’t kept the consistency as we’d like the other way, but we’ve also not gone on a big run like we did towards the end of last season. So there will be a reaction definitely.”
Newcastle United head coach Steve Bruce: “Make no mistake – when you go to Old Trafford, you have to play well, be brave when you have the ball and pose a threat. That’s what we’ll be focussing on.
“We’ve got Manchester United, Everton and Leicester [coming up] – a hard, hard week lies upon us. But that’s the beauty of the Premier League.”